Susceptibility to experimental pyelonephritis when hormonal hypertension is prevented by hypotensive drugs.
نویسنده
چکیده
Rats with desoxycorticosterone (DCA) -saline induced hypertension have been shown to exhibit increased susceptibility to experimental pyelonephritis (1, 2). These studies lend support to the hypothesis that various injuries, including nephrosclerosis, predispose to human pyelonephritis and that pyelonephritis is superimposed upon hypertensive disease more frequently than is usually suspected. Others (3-5) have shown that reserpine and/or hydralazine, when given to rats with DCA-saline hypertension, will reduce blood pressure, delay or prevent renal and vascular pathological changes, and increase the average survival time. Masson, McCormack, Dustan and Corcoran (6) demonstrated a close association between blood pressure levels and the presence and character of the vascular lesions in rats with hydralazine-treated renal hypertension. The previously demonstrated susceptibility of rats with DCA-saline hypertension might have been due either to an effect of the hypertension and vascular disease or to some other effect of the administered steroid and saline. The present investigation was therefore designed to separate these possibilities.
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عنوان ژورنال:
- The Journal of clinical investigation
دوره 39 شماره
صفحات -
تاریخ انتشار 1960